As a result, they should be viewed with a healthy degree of skepticism. It is worth noting that many people report that smoked DMT is extremely clear-headed in its style and tends to produce less personal insight in comparison to orally active psychedelics such as ayahuasca, LSD and psilocybin due to its short-acting nature.ĭisclaimer: The effects listed below cite the Subjective Effect Index ( SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. It is due to a lack of perceived intoxication that many people describe DMT as a genuine experience that is actually happening to them. ĭMT in its smokeable form is reported to be the least mentally inebriating psychedelic. Rick Strassman have both studied and popularized this phenomenon. It's also commonly reported to encounter 'beings' of unknown origin after consuming a high dose of DMT. Subjective effectsĭepending on the dosage and method of administration, the effects of DMT can range from mild psychedelic states to powerfully immersive life-altering experiences which are often described as the ultimate displacement from ordinary consciousness in which users report experiencing ineffable spiritual realms or alternate dimensions. However, the significance of the sigma-1 receptor remains the subject of ongoing scientific research. In addition to this, N,N-dimethyltryptamine is believed to be an endogenous ligand for the sigma receptor. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. Since 1955, the substance has been found in a host of organisms: in at least fifty plant species belonging to ten families, and in at least four animal species, including one gorgonian and three mammalian species.įurther information: Serotonergic psychedelicĭMT's psychedelic effects are believed to come from its efficacy at the 5-HT 2A receptor as a partial agonist. In 1955, a team of American chemists led by Evan Horning isolated and formally identified DMT in the seeds and pods of Anadenanthera peregrina. It was unequivocally identified in 1959, when American chemists were provided a sample of Mimosa tenuiflora.
Its discovery as a natural product is generally credited to Brazilian chemist and microbiologist Oswaldo Gonçalves de Lima who, in 1946, isolated an alkaloid he named nigerina (nigerine) from the root bark of jurema preta ( Mimosa tenuiflora).
It is highly advised to use harm reduction practices if using this substance.ĭMT was first synthesized in 1931 by the German chemist Richard Helmuth Fredrick Manske. However, adverse reactions such as severe anxiety, delusions and psychosis are always possible, even for experienced users, and particularly for those predisposed to mental disorders. Unlike most highly prohibited substances, DMT has not been proven to be addictive or physiologically toxic. Īyahuasca brews have been used traditionally in South America since at least around the year 1500. When ingested in combination with a MAOI or RIMA agent, it becomes active orally and significantly longer lasting, immersive, and interactive in nature: this combination is known as ayahuasca. When vaporized or smoked, DMT produces short-lived effects with a very rapid onset that is sometimes described as an "inconceivably high-speed rollercoaster ride." Īlthough various theories have been postulated, its neurobiological function has yet to be determined. Its presence is also known to be widespread throughout the plant kingdom. It is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is not fully understood.ĭMT is present in over 65 species of plants and has been identified as being a normal constituent of human metabolism and an endogenous neurotransmitter in certain rodents. Among psychedelics, it is known for its unique ability to produce short-lived but intense visionary states and complete hallucinations. N,N-Dimethyltryptamine (also known as DMT, N,N-DMT, Dmitri, and "The Spirit Molecule") is a classical psychedelic substance of the tryptamine class. It is not a recommendation and should be verified with other sources for accuracy. See responsible use section.ĭISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. DMT, N,N-DMT, "Dmitry", "The Glory", "The Spirit Molecule"
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